Proportional Pulse Pressure as a Predictor of In Hospital Mortality among Hospitalized Patients with Heart Failure with Reduced Ejection Fraction

Author : R.A. Farindani, B.G. Napitupulu, H. Hasan
Upload Date : 19-04-2018

Background : Proportional pulse pressure which is pulse pressure divided by systolic blood pressure is known to correlate well with cardiac index in patients with chronic heart failure and positively correlated with invasively measured stroke volume. However, its prognostic significance is unknown in HFrEF patients, although it was predicted that lower PPP would be associated with poorer outcomes. In this study, we investigated the association between PPP on admission with in-hospital mortality in HFrEF patients.

Methods :  113 HFrEF patients  were enrolled in the retrospective study. The data was collected from January 2017 to December 2017. Bivariate and multivariate analysis were applied.

Results : We calculated 78 (69.1%) patients survive and 35 (30.9%) patients dead in this study. In bivariate analysis between PPP and mortality, we found that PPP had good negative correlation (r pearson : 0.62, OR : 26.25, p = 0.00) and more superior than systolic blood pressure and ejection fraction. In the multivariate logistic regression analysis we found that PPP < 0.25 (p = 0.000, OR 27.167)  as a predictor of in-hospital mortality.

Conclusion : Proportional pulse pressure <0.25 was significant to predict in-hospital mortality among hospitalized patient with heart failure with reduced ejection fraction.

KEYWORDS : Proportional Pulse Pressure, HFrEF, Hospital Mortality

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