Association between Biomarkers and Plaque Vulnerability Detected by Optical Coherence Tomography in Patient with Coronary Artery Disease: a Meta-analysis

Author : U. Bahrudin, R.A. Raharjo, S. Herminingsih, I. Uddin, Hardian, Y. Herry, S. Rifqi
Upload Date : 19-04-2018

Background: The vulnerable atherosclerotic plaques of coronary artery disease (CAD) places a patient at risk for developing future major adverse cardiac events. Various biochemical markers have been investigated to predict coronary plaque vulnerability; however, the results remain elusive.

Purpose: To provide a meta-analysis of biomarkers for plaque vulnerability detected by optical coherence tomography in patients with CAD.

Methods: A meta-analysis has been done. Electronic databases were searched up to November 2017. Study quality assessment was performed using Quality Assessment for Diagnostic Accuracy Studies-2. Statistical analyses were done using the Review Manager Version 5.3 and Comprehensive Meta-Analysis Version 3.3.070.

Results: Twenty four articles including a total sample size of 1,923 patients were retrieved. A meta-analysis of 12 studies including 1,152 patients showed that hsCRP had a significant association with thin cap fibroatheroma (TCFA; OR=1.056; p=0.360), while other biomarkers did not: HOMA-IR (OR=0.634; p=0.128), LDL (OR=1.208; p=0.151), HbA1c (OR=1.143; p=0.421), EPA/AA (OR=0.927; p=0.948), and HDL (OR=0.632; p=0.167). Each of biomarkers PTX3, MDA-LDL, elaidic acid, CLR, and adiponectin was reported by one study that they had a significant association with TCFA and could predict its evidence.

Conclusion: The biomarkers hsCRP might be able to predict the vulnerability of coronary atherosclerosis plaque, while EPA/AA, PTX3, MDA-LDL, elaidic acid, CLR, and adiponectin should be further studied to establish their accuracy in detecting the vulnerability.

KEYWORDS : Coronary artery disease, plaque vulnerability, optical coherence tomography, biomarker.

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