Lipid Profile and Itâ€™s Association with Multivessel Coronary Artery Disease on Patients Who Underwent Coronary Angiography in Abdul Wahab Syahranie General Hospital Samarinda
Author : D. Budiono, O.M.S Nasution, M.D.Pratama , D. Herdianto
Upload Date : 19-04-2018
Background: Dyslipidemia is considered as one of the most common modifiable risk factors of CHD, but their association with disease severity remains controversial and could differ according to ethnic origin and geographic area. This study aims to evaluate the association between lipid profile and multivessel coronary artery disease on patients who underwent coronary angiography in Abdul Wahab Syahranie General Hospital.
Methods: This study was an observational study with cross-sectional design. Seventy-seven patients who underwent coronary angiography in Abdul Wahab Syahranie General Hospital in 2017 were included. Data were collected from medical record. The association of profil lipid and multiple vessel disease were analyzed using Student's t-tests.
Results: There are 24 (31.20%) patients with single vessel disease or insignificant lesion and 53 patients (68.8%) with multivessel disease. The mean of lipid profile in patients without multivessel disease vs with multivessel disease were following: Total Cholesterol 174.54±41.01 mg/dL vs 194.33±38.79 ; triglyceride 100.67±50.97 vs 154.75±82.81; HDL 46.79±8.50 vs 43.51±8.87; LDL 107.71±35.57 vs 122.28±38.37. The association between lipid profile with multivessel coronary artery disease were following: Total cholesterol: p=0.045; Triglyceride p=0.001; HDL-cholesterol: p=0.132; LDL-cholesterol: p=0.119.
Conclusion: Patients with multivessel coronary artery disease have higher level of total cholesterol, triglyceride, LDL cholesterol, and lower level of HDL cholesterol. Total cholesterol and triglyceride are statistically significant associated with multivessel coronary artery disease, meanwhile HDL-cholesterol and LDL-cholesterol are not that significant.
KEYWORDS : Low density lipoprotein, high density lipoprotein, triglyceride, total cholesterol, multivessel coronary artery disease
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