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Association Between Glycated Hemoglobin with Severity of Coronary Artery Disease in Non-Diabetic Patients

Author : I.M Raditya, M. Syafri, M. Yanni
Upload Date : 19-04-2018

Background : Glycated hemoglobin (HbA1c) is known as one of the diagnostic markers of diabetes mellitus, but some hypotheses suggest that HbA1c also plays an important role in the progression of atherosclerosis. Studies that assessed the association of HbA1c levels with the severity of coronary artery disease, particularly in nondiabetics, have not been widely practiced. 

Methods : The study was cross sectional, evaluating the association between HbA1c levels with severity of coronary artery disease assessed with SYNTAX score in patients with nondiabetics acute coronary syndrome at Dr. M. Djamil Hospital who underwent coronary angiography.

Results : Of the 71 patients enrolled in the study, 34 patients were included in the group with low coronary artery disease severity (SYNTAX score ≤22), while 37 patients belonged to the group of intermediate-high coronary artery disease severity (SYNTAX score> 22). There was a significant difference between the mean levels of HbA1c in the group of low coronary artery disease severity and intermediate-high  coronary artery disease severity (5.55 ± 0.29% vs. 5.78 ± 0.32%, respectively) with p <0.002.

Conclusions: HbA1c levels were significantly associated with coronary artery disease severity assessed with SYNTAX Score in nondiabetic acute coronary syndromes patients.

KEYWORDS : coronary artery disease, severity, HbA1c, SYNTAX score, nondiabetics.


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