Advanced

Association between Statin Use as Primary Prevention and Outcomes in Acute Coronary Syndrome Patients during 2016 in Cengkareng General Hospital, Jakarta

Author : A. Priyana, A. F. Sunjaya, A. P. Sunjaya
Upload Date : 19-04-2018

Background: Cardiovascular disease, mainly Acute Coronary Syndrome (ACS), is the leading cause of death in the world today, including Indonesia. ACS often leads to increasing risk of numerous life threatening complications, such as malignant arrhythmia, pulmonary edema, and cardiogenic shock. Statin, the drug of choice for dyslipidemia, is widely used as a primary prevention for coronary artery disease. Moreover, it is essential in reducing mortality in ACS patients, either due to its LDL lowering or pleiotropic effects. Giving statin as primary prevention, therefore, may not only benefit in preventing ACS incidence, but also contribute towards lowering the incidence of complications in ACS patients.

Methods: A retrospective non-randomized study was conducted in 2016 involving 145 ACS patients at Cengkareng General Hospital. History of statin use was recorded, as well as ACS complications such as cardiogenic shock, malignant arrhythmia, pulmonary edema, and death. GRACE score was also compared between ACS patients who had received statin regularly with those who had not receive statin.

Results: Only 10.3% of ACS patients were found to receive statin for primary prevention. LDL values did not significantly differ between both groups. No significant differences in the incidence of complications were found between patients who received statin and those who didn’t. Compared to non-statin group, patients in the statin group showed lower proportion of cardiogenic shock, pulmonary edema, and mortality. GRACE score was found to be lower in the statin group, although not statistically significant.

Conclusion: This study showed that statin use for primary prevention was still very low among patients in West Jakarta. On the other hand, statin use in those patients might give potential benefits in preventing ACS complications and death. Larger and further comprehensive prospective studies are needed to evaluate the risks and benefits of statin as primary prevention of ACS.

KEYWORDS : statin, acute coronary syndrome, complications, death


Save Item
Download
Similar Articles

High Intensity Statin in Patient with Acute Coronary Syndrome, Why and How?(Mohammad Saifur Rohman)

Clinical Picture and Risk Prediction of Short-Term Mortality of Mechanically Ventilated Patients Presented with Cardiogenic Shock in Intensive Cardiovascular Care Unit of Saiful Anwar General Hospital(H. A. Liemena*, F. W. Nugroho, D. H. Karimullah, Setyasih Anjarwani)

Right Ventricle Function as Predictor Inhospital Mortality in Acute Coronary Syndrome Patient’s in CCU Sarjito General Hospital (M. Suryantoro , H. P. Bagaswoto ,N. Taufiq , B. Y. Setianto)

Hemoglobine Level as Predictor of Inhospital Mortality in ACS Patients SCIENCE Registry Sub-Study(A. R. Gemilang, H. Purnasidha, N. Taufiq, B. Y. Setianto)

Profile of Dippers and Non Dippers Hypertension Patient in General Hospital Doctor Mohamad Saleh Probolinggo(M. A. Pasha; T. Ardhana)

Thrombocyte-to-Leukocyte Ratio is correlated with Length of Stay in Patients with ST-Elevation Myocardial Infarction Underwent Primary Percutaneous Coronary Intervention(Y.S. Pratama, R. Puspitoadhi, N.A. Tafriend, U. Bahrudin)

Diagnosing and Treating Left Bundle Branch Block ECG Finding as An Acute Coronary Syndrome Event in Rural Hospital of East Sumba: A Case Report(T.S.R. Sembiring)

Polycythemia Vera as the Main Risk Factor in ST Elevation Myocardial Reinfarction(W.D.S. Cyndiana, B. Kris, A. Wayan)

Pseudonormalization ST-segment in ST-elevation Myocardial Infarction Patient(F.Fathini, R. A. Seriulina,A. Ginanjar, T. T. Dewi, I.A. Rakhmawulan, D. Rostiati)

Left Ventricular Ejection Fraction in correlation with In Hospital Mortality in ACS Patients: SCIENCE Registry Sub-Study (B.A. Prabowo, H.P. Bagaswoto, N. Taufiq, B.Y. Setianto)

Definite Sub Acute Stent Thrombosis after Primary Percutaneous Coronary Intervention(G.Aditya, W. Aryadana)

Copyrights © 2018 ASMIHA | Managed by Indonesia Medical Event (IME)