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Correlation Between Lipid Profile and Carotid Intimal Medial Thickness in Women Systemic Lupus Erythematous Patients in Hasan Sadikin General Hospital

Author : A. Kusumaputri, E. Chandra, Mardlatillah, S. Hidayat, L. Hamijoyo, M. R. Akbar, A. Purnomowati, T. M
Upload Date : 19-04-2018

Background. Systemic Lupus Erythrematous (SLE) in women is a complex disease characterized by an inflammatory process that affects many organs and tissues, also involves increased risk of atherosclerosis. The early identification of cardiovascular risk in this population is still challenging. The study of endothelial thickness, represented by Carotid Intimal Medial Thickness (C-IMT) and the evaluation of other lipid biomarkers have been proposed. The aim of this study is to evaluate the correlation between of those two.

Methods. This is a cross-sectional study conducted at Hasan Sadikin Hospital Bandung, between August until October 2017. There were 78 women with SLE based on American College of Rheumatology (ACR) 1997 criteria during this periode, but only 71 patients are included for further analysis. C-IMT performed using Dupplex ultrasonography. Lipid profile (total cholesterol, low-density lipoprotein, high-density lipoprotein, triglycerides) measured by spectrophotometry using enzymatic colorimetric method. We used Spearman’s correlation test to analyze the correlation between C-IMT and lipid profile.

Results. The median age of this study was 34 (19-61) years old. The median of LDL, HDL, TG, total cholesterol were 108 (52-345), 56 (34-144), 109 (32-297), 186.23 + 53.06 mg/dl respectively.  The median of C-IMT 0.76 (0.56-1.62) cm. Correlation between C-IMT and LDL, HDL, TG, total cholesterol were as followed: 0.419 (0.201-0.637) (p<0.001), -0.499 (-0.708 - -0.292) (p<0.001), 0.462 (0.249-0.675) (p<0.001), 0.419 (0.201-0.637) (p<0.001).

Conclusion. There is strong correlation between C-IMT and LDL in women SLE patient. Other parameter used in this study such as total cholesterol, HDL, and triglyceride has moderate correlation. Lipid profile should be monitored to prevent acceleration of atherosclerosis in SLE patients.

KEYWORDS : C-IMT, Lipid profile, SLE, Women

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