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Estimated Glomerular Filtration Rate And Length of Stay in Patients with ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Author : H. Haryadi, A. A. Asrial, L. Raharjoyo, N. Virginia, K. Rizky ,Y. Herry
Upload Date : 19-04-2018

Background: Renal dysfunction has been proven to impair outcomes, including prolonging Length of Stay (LoS), in patients with myocardial infarction. Prolonged LoS will increase cost and risk of nosocomial infection. The aim of the study is to investigate the impact of estimated glomerular filtration rate (eGFR) on LoS in patients undergoing primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI).

Methods: A retrospective study was conducted using medical record, catheterization laboratory and echocardiography laboratory data between Januari 2016 – Mei 2017 at Kariadi Hospital Semarang. A total of 46 patients were divided into three groups according to eGFR (mL/min/1.73 m2): normal renal function (RF) group (eGFR ≥60, n=27), decreased renal function group (eGFR 60 - 30, n=19) and low renal function group (eGFR < 30, n=3). Mean differences between each group was analyzed using one way ANOVA with significance of 0.05 and 95% of cofidence interval. Estimated glomerular filtration rate was calculated based on creatinine level upon admision before primary angioplasty. Length of Stay (LoS) was defined as days of hospital stay from admission until discharge.

Results: Age, heart rate, creatinine level and GRACE score were significantly different between three groups (p <0.05). With low and decreased in eGFR, in-hospital LoS is longer than normal eGFR  (5.89 ± 1.67 vs 7.19 ± 3.51 vs 8.67 ± 3.21), but statisticaly not significant (p:0.11). In three group, hypertension is the highest portion as medical history with 66.67% in low eGFR group, 87.50% in decreased eGFR group and 62.96%  in normal eGFR group.

Conclusion: Data of this study showed that length of stay in decreased and low renal function group (eGFR 60 – 30 and eGFR <30) STEMI patient undergoing PPCI is longer than normal renal function group (eGFR >= 60) but statisticaly not significant different.

KEYWORDS : estimated glomerular filtration rate, length of stay, myocardial infarction


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