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A Meta-analysis: Associations Between Polymorphisms Gene in Chromosome 9p21 and Risk Of Aortic Aneurysm

Author : R. Mahardhika , M.F. Huda, R. Mahardina, R. M. Budiarto
Upload Date : 19-04-2018

Background: Many associations between  aortic aneurysm  and genetic polymorphisms have been reported. The molecular mechanisms responsible for the increased risk of aortic aneurysm are unknown, but interestingly, polymorphisms  gene in chromosome 9p21, has been known to play a role in the development of aortic aneurysm. Some types of single nucleotide polymorphisms (SNPs) gene have been reported to exert risk of aortic aneurysm.

OBJECTIVE:

This study aims to analyze the relationship between variants of SNPs rs10757278 and rs1333049 with  the risk of aortic aneurysm

Methods: We conducted a comprehensive search to identify all eligible studies from PubMed, MEDLINE, EBSCO, ProQuest, Science Direct, and Cochrane databases for case-control studies to evaluate the relationship between two types of SNPs.  All studies were assessed under Hardy-Weinberg Equilibrium, additive model. The meta-analysis was performed by RevMan 5.3 (fixed-effects and random-effects model based on heterogeneity test) to provide pooled estimate for odds ratio (ORs) with 95% confidence intervals (95% CIs). Our primary outcome was risk of aortic aneurysm for each type of SNPs.

Results: Seven clinical studies met our inclusion criteria and included a total of 14.236 patients. These studies included 3.134 patients with aortic aneurysm and 11.102 were controls. The crude odds ratio (ORs) of meta-analysis under 2 variants SNPs were associated with aortic aneurysm  in which rs10757278 polymorphism increase the risk of aortic aneurysm (odds ratio(ORs)=1.68 (95% CI, 1.38-2.13);p=0.00001, I2=83%},  And variant rs1333049    {odds ratio(ORs)=1.53 (95% CI, 1.11-1.89); p=0.002, I2=73%}.

Conclution; These results suggested that rs10757278 and, rs1333049 polymorphism might contribute in developing aortic aneurysm

KEYWORDS : 9p21 chromosome, single-nucleotide polymorphisms (SNPs), aortic aneurysm

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