Relationship Of Platelet Distribution Width And Mean Platelet Volume with ST Segmen Resolution After Fibrinolytics On ST Elevation Myocardial Infarction Patients at Haji Adam Malik General Hospital Medan

Author : D. Ashrinda, H. Hasan, N. Z. Akbar, Z. Mukhtar
Upload Date : 19-04-2018

Background: Platelet activation has an important role in occurrence and progression of myocardial infarction. The value of Platelet Distribution Width (PDW) indicates platelet form heterogeneity, this examination may be a sign of platelet reactivation. Mean Platelet Volume (MPV) is the average platelet size in peripheral blood circulation. Increased PDW and MPV values increase the incidence of coronary thrombus and fibrinolytic failure in ST Elevation Myocardial Infarction (STEMI) patients.

Methods: This was a cross-sectional study to assess the relationship of PDW and MPV to ST-segment resolution (STR) in STEMI patients with fibrinolytic therapy at Haji Adam Malik General Hospital, from January 2015 to December 2016. The sample is divided into two groups, namely ST segment resolution (STR) ³ 50% and STR < 50%. STR was assessed by measuring alteration of ST segment before and after fibrinolytic.

Results: A total of 53 patients (mean age 52 ± 8 years, 51 male 2 female) had fibrinolytic therapy with Streptokinase, 33 patients with STR ³ 50% and 20 patients with STR < 50%. Risk factors affecting STR was diabetes mellitus (DM) (p=0.030). Bivariate analysis showed that DM (p=0.030; OR 0.269), onset of chest pain = 3 hour (p=0.013; OR 2.80), MPV value < 10 fL (p=0.007; OR 4.95), PDW value <11% (p=0.031; OR 3.59) and Troponin T = 0.03µg / mL (p=0.008; OR 6.02) had a significant relationship to STR. Then all variables were performed multivariate analysis obtained MPV <10 fL (p=0.012; OR 5.08) and Onset Chest Pain = 3 h (p=0.044; OR 4.08) have a stronger relationship with STR.

Conclusion: MPV has a strong relationship with ST segment resolution after fibrinolytic in STEMI patients.

KEYWORDS : PDW, MPV, ST Segment Resolution, Streptokinase

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