The Comparison of Sensitivity and Specificity of Point of Care Testing Next Generation Troponin I and High Sensitive Troponin I in Acute Myocardial Infarction Patients
Author : Kriswanto, M. Aminuddin, J. Nugraha
Upload Date : 19-04-2018
Background: Increase in Troponin I (TnI) level is one of criteria for diagnosing Acute Myocardial Infarction (AMI). Several TnI diagnostic methods with enhanced analytic sensitivity has been developed recently, such as high sensitive TnI (hs-TnI) and the newer is Point-of-Care Testing (POCT) next generation TnI (ng-TnI).
Objective: The aim of this study was to compare diagnostic sensitivity and spesificity between POCT ng-TnI and hs-TnI in patients with AMI.
Methods: This is a cross-sectional study with diagnostic test design in August- October 2016. Using purposive sampling, 82 patients Emergency Room Dr. Soetomo Hospital Surabaya with angina pectoris who met the criteria were included and examined for ng-TnI level using POCT Fluorescent Energy Transfer Latex method (Alere Triage MeterPro®) and hs-TnI level using Chemiluminescent Enzyme Immunoassay method (Mitsubishi Pathfast®). Sensitivity and Specificity of POCT ng-TnI Alere dan hs-TnI Pathfast calculate with 2x2 Tabulation and The Area Under Curve (AUC) with ROC curve.
Results: A total 82 patients, 32 patients (39%) were diagnosed as AMI and 50 patients (61%) were non AMI. The sensitivitity of POCT ng-TnI and hs-TnI in AMI patient with a cut off 0.02 ng/ml were 100%, the specificity were 56% and 64%, AUC were 0.914 and 0.911 (p <0.05).
Conclusion: There is no statistical difference about sensitivity and AUC between POCT ng-TnI and hs-TnI in AMI patients. Both TnI assays showed a very good value for IMA diagnostic tool.
KEYWORDS : AMI, high sensitive Troponin I (hs-TnI), Point-of-Care Testing next generation TnI (POCT ng-TnI), Sensitivity, specificity, AUC.
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