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Comparison of Interleukin-6 Post Percutaneous Coronary Intervention between Patients with Acute Myocardial Infarction that Underwent Complete and Incomplete Revascularization

Author : P. K. Dewi, S. Rifqi, N. Anggriyani, N. Wijayahadi
Upload Date : 19-04-2018

Aims or Background: Percutaneous coronary intervention (PCI) is one of the invasive procedure options for  acute myocardial infarction (AMI) patients with single vessel disease (SVD) or multivessel disease (MVD). Incomplete PCI in patients with MVD and unstable residual plaque is associated with poorer prognosis and higher major adverse cardiovascular events (MACE) rate. IL-6 is an inflammatory marker that can predict adverse cardiovascular events in AMI patients. Aims of this research is to compare IL-6 level change after PCI in AMI patients undergoing complete  and incomplete revascularization.

Method: The study subjects are all NSTEMI and STEMI patients with onset of symptoms ≤1 week who underwent PCI in dr. Kariadi Central General Hospital Semarang in October to December 2016 that met the inclusion criterias. Subjects are divided into two groups, the complete and incomplete revascularization groups according to the PCI result. IL-6 examination was done for all subjects using the peripheral blood samples within 24 hours after PCI and 1-2 weeks after PCI.

 Results: 40 patients (mean age: 54.55 years old) were divided into two groups: 19 patients (47.5%) had complete revascularization and 21 patients (52.5%) had incomplete revascularization. There was a significant decrease of IL-6 level in both groups with p<0.001 and p<0.006, respectively. Delta (?) of IL-6 level between the two groups was significantly different (p=0.01).

Conclusion: IL-6 level was significantly decreased in both groups. Delta (?) of IL-6 level in AMI patients undergoing complete revascularization was higher compared to that in patients undergoing incomplete revascularization.

KEYWORDS : Acute myocardial infarction, interleukin 6, percutaneous coronary intervention.

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