Association of ß angle with Arrhythmic Events in Brugada Syndrome with ECG type 2 and 3

Author : C. Candra, S. B. Raharjo, D. Yugo, D.A. Hanafy, Y. Yunadi
Upload Date : 19-04-2018

Background. Brugada syndrome is known to be the cause of at least 4% of all sudden deaths and 20% of sudden deaths in structurally normal hearts. To this day, only type 1 Brugada Syndrome ECG pattern is diagnostic, while type 2 and 3 are not. A ß angle ≥ 58o has a good diagnostic value in population with Brugada ECG pattern type 2 and 3. This study aims to evaluate whether this parameter is associated with arrhythmic events in patients with Brugada Syndrome type 2 and 3.

Methods. This case-control study is carried out towards 29 subjects with Brugada ECG pattern type 2 and 3 in National Cardiovascular Center Harapan Kita (NCCHK) from November 2013 until November 2017. Thirteen subjects with history of arrhythmic events make up the case group while 16 subjects without arrhythmic events make up the control group. Primary data acquired was history of sudden cardiac arrest, documented VT/VF, history of syncope suspected of arrhythmic origin and family history, and also interrogation data from implantable cardioverter defibrillator (ICD) in subjects with ICD. Secondary data were ECG data, from which ß angle was measured in the right precordial leads by two observers, and then statistical analysis was carried out.

Results. From ß angle measurement by two observers, there was not a significant difference with Cronbach’s Alpha of 0,93. Statistical analysis showed no significant association between a ß angle ≥ 58o and arrhythmic events. Correlation analysis was carried out, and a positive correlation was shown (r=0,50, p<0,05) between ß angle and arrhythmic events.

Conclusion. There is no significant association between ß angle ≥ 58o and arrhythmic events in Brugada syndrome. There is a positive correlation between this parameter and number of arrhythmic events, but this finding needs to be further evaluated.

KEYWORDS : ß angle, Brugada syndrome

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