Distributon of Multiple Vessels Coronary Artery Disease and Risk Factors in Patient with Acute Coronary Syndrome: Study From Sardjito General Hospital Registry

Author : A. Pradhana, H.P. Bagaswoto, N. Taufiq, B.Y. Setianto
Upload Date : 19-04-2018

Background: Coronary Artery Disease (CAD) is an important medical and public health problem with an approximately 7.2 million deaths/year, or 12% of all deaths worldwide annually and the single most important cause of death in developed countries. Traditional Cardiovascular Risk Factors (TCRF) such as male sex, advancing age, Diabetes Mellitus (DM), and hypertension, are well recognized for their association with clinical events and Acute Coronary Syndrome (ACS). However, the distribution of multiple vessels CAD and TCRF, assessed angiographically, is not as well established, with studies reporting variable and inconsistent results.

Method: This is a descriptive study with subjects taken from SCIENCE (Sardjito Cardiovascular Intensive Care and Acute Coronary Syndrome) registry from Sardjito General Hospital Yogyakarta between January and October 2017. The purpose of our study was to explore the distribution of multiple vessels CAD and TCRF in patients underwent coronary angiography at our institution.

Result: There were 550 patients with ACS who registered in SCIENCE registry. Seventy point two percent had ST Elevation ACS (STE-ACS) and 29.8% had Non-ST Elevation ACS (NSTE-ACS). The STE-ACS group was predominantly in male patients (81.8%) without DM comorbidity (75.6%). The NSTE-ACS group was predominantly in high risk stratification (42.1%). Among high risk NSTE-ACS stratification patients, 77.1% had at least hypertension as the TCRF. Whereas, only 27.1% patients had at least DM as the TCRF. From 367 ACS patients who underwent coronary angiography, 63.4% had at least 2 vessels CAD and were predominantly in hypertension (59.6%) and elderly (≥ 60 years old) patients (58.3%). But only DM had a significant association with multiple vessels CAD (OR= 1.182 [95% CI: 1.014-1.379], p= 0.043)

Conclusion: Hypertension is the most prevalent TCRF in high risk NSTE-ACS stratification patients. DM is the TCRF associated significantly with multiple vessels CAD.

KEYWORDS : Coronary artery disease, traditional cardiovascular risk factors, NSTE-ACS

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