A Study of Correlation between Carotid Intima-Media Thickness and Left Ventricular Hypertrophy in Obese Patients
Author : G.P. Lumentut, A. L. Panda, J. Pangemanan, M. Rotty, T. J. Sumampouw, N. O. H. Rantung, H. Pribadi
Upload Date : 19-04-2018
Background: Obesity is becoming a global epidemic in both children and adults.1 It is associated with numerous comorbidities such as cardiovascular disease. Obese subjects have a high prevalence of left ventricular hypertrophy (LVH)2, while it also related to increase in carotid intima-media thickness (cIMT) as a sign of subclinical atherosclerosis.3 This study aims to evaluate the correlation between LVH with cIMT in obese patients.
Methods: A cross-sectional study, included 40 patients with body mass index (BMI) more than 25 kg/m2, aged between 40 to 60 years, underwent basic physical examination, carotid ultrasound and echocardiography. BMI was calculated based on participant height and weight, echocardiography used to determine LVH, and cIMT was examined by carotid ultrasound.
Results: This study observed 23 women (57.5%) and 17 men (42.5%) with obesity, the mean of age was 51.48 years. In obese women, 10 patients shown abnormal cIMT (25%) and 14 patients with LVH (35%). While obese men reported 9 cases of abnormal cIMT (22.5%) and 13 cases of LVH (32.5%). 10 patients with normal cIMT has experienced of LVH, while 3 patients with abnormal cIMT Thickening in carotid intima media showed statistically significant correlations with the presence of LVH in patients with obesity (r=0.301, p=0.032).
Brief discussion: The findings demonstrate that in obese patients, the presence of cIMT as an early arterial wall changes, related to hypertrophy of left ventricle. The current study is consistent with the results from other studies that LVH and increased cIMT are independently predictive of cardiovascular morbidity and mortality in adult.4
Conclusion: There was a positive correlation between cIMT and LVH in obese patients. Beside a routine echocardiography, measurement of carotid artery should be performed in all patients with obesity for an early detection of cardiovascular disease.
KEYWORDS : carotid intima-media thickness, left ventricular hypertrophy, obesity, cardiovascular disease, ultrasound
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