The Correlation of Polyunsaturated Fatty Acid-Monounsaturated Fatty Acid Plasma Ratio with Left Ventricular Ejection Fraction in Patients with Stabil Chronic Heart Failure

Author : I. Puspita, M. R. Akbar, S. Hidayat
Upload Date : 19-04-2018

Background. The vicious cycle of chronic heart failure is mediated by neurohormonal activation mechanism. Optimal heart failure therapy until now includes the suppression of neurohormonal activation, diuretics, hemodynamic control and cardiac device, but heart failure is still often found to be progressive and to have a poor prognosis. Innovative therapies with supplementation of Polyunsaturated Fatty Acids (PUFAs) and Monounsaturated Fatty Acid (MUFA) have been researched and proven to be beneficial, but still found weaknesses of each such supplementation. Analysis of PUFA-MUFA ratio was better than seeing levels per fatty acid component. Studies looking at the ratio of plasma PUFA-MUFA are still few and up to now there has been no studies that analyze the relationship between PUFA-MUFA ratio with a value of left ventricular ejection fraction (LVEF) that reflect the heart function of patients with chronic heart failure.

Methods. This research was conducted in a single- center with cross-sectional design. In this study, patients with stable chronic heart failure were treated at the Heart Polyclinic of dr. Hasan Sadikin hospital, the period from July 2016.PUFA and MUFA plasma levels were determined by using gas chromatography mass spectromethry (GCMS). The value of left ventricular ejection fraction was determined by echocardiography.

Result. A total of 36 patients with stable chronic heart failure were included in this study(61.1% male, average age 58+13 years old). The average ratio of PUFA-MUFA was 0.561784+0.232264 and the average value ofLVEF was 51.4+12%. There was a significant positive correlation (r =0.646, p<0.01) between the ratio PUFA-MUFA and LVEF  value.

Conclusion. There is a significant positive correlation between the ratio of  plasma PUFA-MUFA with LVEF value.

KEYWORDS : chronic heart failure, LVEF, MUFA, PUFA

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