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Relation between Adiponektin Level with The Right Ventricular Function in Adult Uncorrected Secundum Atrial Septal Defect Patient

Author : D. Aji,W. Himawan ,D. W. Anggraini , A. B. Hartopo , L. K. Dinarti
Upload Date : 19-04-2018

Backgorund.   Fifty six out of ten thousand child births have atrial septal defect as congenital heart anomaly. The incidence is relatively high compared to other congenital anomalies. Shunt from left to right heart chambers occured in ASD which make volume and pressure overload in the right heart chambers . The clinical manifestasion of ASD is vague hence it is not easily diagnosed since childhood. With the advancement of age, the volume and pressure of the right heart become more severely increased. Adiponectin is a kind of adipocytokines released from fatty tissue to circulation. This substance has a role to prevent cardiac muscle hypertrophy especially from the impact of pressure and volume overload.

Methods. Adult patients with uncorrected secundum atrial septal defect were registered in Dr Sarjito Hospital studied with a cross sectional method. The patients that involved in this study were patients with uncorrected atrial septal defect. We measured right ventricular function in TAPSE via echocardiography examination. The decreased of right ventricular was defined as TAPSE point less than 17 mmHg. Venous blood sampling were taken from brachial vein  and adiponectin plasma level measured using ELISA technique.

Results. Eighty seven subject were participated in this study, the mean age is 36 years old and the majority of subject are female (88%). We found no significant correlation between right ventricular function and adiponectin level (p < 0.771) 

Conclusions. Adiponektin level was not statistically significant correlated with right ventricular function in adult uncorrected patient with ASD.

KEYWORDS : Adiponectin levels; atrial septal defect; Congenital Heart disease, Right Ventricular Function.


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