Correlation between High Sensitive C-Reactive Protein and Left Atrial Volume Index in Young Adult with Obesity

Author : A. Ridha, A. Saboe, M. R. Akbar, A. Purnomowati, T. M. Aprami
Upload Date : 19-04-2018

Background: Obesity is one of the global problems whose prevalence continue to increase. Left atrial involvement is one of obesity-related complications. Obesity is associated with alterations in the left atrial volume index (LAVi) with controversial pathomechanisms. One of the evolving theory is caused by chronic systemic inflammation, characterized by the increase of C-Reactive Protein (CRP) in obesity. High sensitive C – Reactive Protein (hs-CRP) is a sensitive methods to measure CRP. This study aims to investigate the correlation between hs-CRP and LAVi in young adults with obesity.

Methods: This study was conducted in a single center with cross-sectional design to all young adults with obesity (Body Mass Index >30 kg/m2 using WHO criteria) that worked in Hasan Sadikin General Hospital, Bandung, during August-November 2017. LAVi  was measured by 2D Echocardiography using biplane method and performed by 2 experienced cardiologist. The particle enhanced turbidimetricassay were done to measured hs-CRP. The correlation between hs-CRP and LAVi  was analyzed using Pearson correlation.

Results: A total of 29 patient (69,0% male, 30.55 + 5.38 years old) were included in this study. The average of hs-CRP level was 8,8 (1.07 – 35.1) mg/L and the average of LAVI was 16.61 ± 4.45. After data log transformation of hs-CRP, there was a correlation between the hs-CRP and LAVi  in young adults with obesity. (r= -0.542, p=0.001)

Conclusion: There was a significant positive correlation between the hs-CRP and LAVI in young adults with obesity. Increase of hs-CRP level indirectly affects left atrial dimension. Further study is needed to investigate other factors contributes to LAVi magnification.

KEYWORDS : hs-CRP, left atrial volume index, obesity, young adult

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