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The Clinical Outcome Comparison of Ischemic Stroke with Ischemic Heart Disease and without Ischemic Heart Disease

Author : N.H. Karunawan, R.T. Pinzon
Upload Date : 19-04-2018

Background: Stroke and Ischemic Heart Disease are the leading cause of morbidity and mortality in worldwide. Ischemic stroke after ischemic heart disease is an important complication. The occurrence in ischemic heart disease patients is associated with increased morbidity and mortality. This study aims to compare the clinical outcome of ischemic stroke patients with ischemic heart disease  and without ischemic heart disease.

Methods: This comparative study of 200 patients were first time acute ischemic stroke recorded in the Bethesda Hospital Yogyakarta Stroke Registry (2012-2017). These patients were divided into ischemic stroke patients with ischemic heart disease and ischemic stroke patients without ischemic heart disease. The primary outcome of the study were in-hospital mortality, disability measured by modified Rankin Scale (mRS), and length of stay. The data were analyzed univariate and bivariate followed by the Chi-square test and Mann-Whitney.

Results: Data of 200 patients with 100 stroke patients with ischemic heart disease consist of fourty-two male (42.0%) and eighty-six (86.0%) were more than 50 years old. Compare to 100 stroke patients without ischemic heart disease consist of fourty-two male (42.0 %) and eighty-nine (89.0%) were more than 50 years old. The mortality of stroke patients with ischemic heart disease group is eighteen patients (18.0%), sixty patients (60%) have poor functional outcome (mRS >2) and have length of stay 10.26 ± 8.39 days. Bivariate analysis showed stroke patients with ischemic heart disease group is significantly associated with higher in-hospital mortality (RR:2.9, 95%CI:1.1–7.3, p<0.019),worse disability (RR:2.6, 95%CI:1.3 –5.1, p<0.005) and prolonged hospital stay (10.26±8.39 vs 4.59±2.57, p<0.001) than in stroke patients without ischemic heart disease group.

Conclusion: Ischemic stroke patients with ischemic heart disease is significantly associated with higher in-hospital mortality, worse disability, prolonged hospitalization than in ischemic stroke patients without ischemic heart disease.

KEYWORDS : ischemic heart disease, ischemic stroke, comparison, outcome

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