The effect of Syzygium Polyanthum (Wight) Extract on Lipid Accumulation and Metabolic Parameters in Hyperlipidemic Male Wistar Rats
Author : H. M. Salim, L. K. Farizqi, T.W. Bintarti, Handayani
Upload Date : 19-04-2018
Background; Lipid accumulation in the liver and pancreas is primarily caused by combined hyperlipidemia. Syzygium polyanthum (Wight) Walp. var. polyanthum leaves are consumed as a traditional Indonesia treatment. However, the effect of extract Syzygium polyanthum (Wight) Walp in isolated hypercholesterolemia is not fully described. Therefore, our aim was to investigate whether extract Syzygium polyanthum (Wight) Walp decreased the hypercholesterolemia leads to alterations in histology of hepatic lipid in Wistar rats.
Methods and Results; Hypercholesterolemia in Wistar rat was induced by oral administrated of high fat diet (HFD) of lard (2ml/200g). Two weeks after HFD, the extract Syzygium polyanthum (Wight) on dose dependent (0.72mg/kg/day, 0.9 mg/kg/day, and 1.08 mg/kg/day) was administrated via oral gavage for 4 weeks. Treatment with extract of Syzygium polyanthum (Wight) reduced cholesterol total levels (P<0.05) in hyperglycemic Rat model. Also, decreased the others metabolic parameters high-density lipoprotein (HDL) (P<0.05), and triglyceride (TG) (P<0.05) with alteration of body weight and blood glucose. Furthermore, the histology analysis demonstrated that, in hypercholesterolemia rat model, the extract of Syzygium polyanthum (Wight) reduced the isolated hypercholesterolemia lipid accumulation in liver (p < 0.05).
Conclusion; Cholesterol-total lowering effects of extract Syzygium polyanthum (Wight) were associated with the reduction of lipid accumulation in the liver in hypercholesterolemia Wistar Rat model. These results may provide a possible mechanism for hepatoprotective and cardioprotective effects of extract of Syzygium polyanthum (Wight).
KEYWORDS : Hypercholesterolemia, lipid accumulation, Syzygium polyanthum (Wight)