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Soluble ST2 Level Correlates with Mean Pulmonary Artery Pressure in Adult with Uncorrected Secundum Atrial Septal Defect: A Novel Study

Author : R. S. Pratama, A. B. Hartopo, D. W. Angrahini, L. K. Dinarti.
Upload Date : 19-04-2018

Background: Secundum atrial septal defect (ASD II) is the most common congenital heart defect that affects adult. If left uncorrected, it may develop into pulmonary arterial hypertension (PAH) which diminish the life expectancy. Soluble ST2 (sST2) is a member of the interleukin 1-receptor family, which increases in response to cardiomyocyte biomechanical strain. It has been proposed to be a marker in patients with left heart failure. The role of sST2 in ASD II is yet to be studied before. In this paper we study the correlation between the level of sST2 and mean pulmonary arterial pressure (mPAP) of adult patients with an isolated ASD II.

Methods: The study was cross sectional. We enrolled 56 patients with uncorrected isolated ASD II. Mean pulmonary arterial pressure was assessed by right heart catheterization (RHC). Blood was drawn at the time of RHC from pulmonary artery for plasma sST2 level measurement which is done with cartridge-based immunofluorescence kit. Correlation between sST2 and mPAP was done with Spearman correlation analysis.    

Results: There were 56 ASD II patients (49 females) with mean age of 33.04±12,051 years. We found significant correlation between sST2 with mPAP (r = 0.459, p < 0.05).

Conclusion: There is a significant correlation between sST2 with mPAP (r = 0.459). This result may provide a basic knowledge for further research regarding the role of sST2 in patient with ASD II

KEYWORDS : sST2, Atrial Septal Defect, Pulmonary Artery Pressure

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