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Testosterone Links to Interleukin-10 in Male Patients with Rheumatic Heart Disease

Author : F Ahnaf, U. Bahrudin, P. Ardhianto, I. Pawitra, S. Budijitno, Y. Herry
Upload Date : 19-04-2018

Background: Rheumatic heart disease (RHD) is an autoimmune disease which occurs less common in males than females. Testosterone is suggested to have a role in the pathogenesis of autoimmune disease, however its role in the inflammation process in RHD remains unknown.

Purpose: To investigate correlation between the calculated free testosterone (cFT) and interleukin 10 (IL-10) expression in male RHD.

Methods: A cross sectional study including 17 male RHD patients undergoing mitral valve replacement surgery at the Dr. Kariadi Hospital. Two patients were excluded due to infective endocarditis. Level of the serum testosterone was measured using ELISA, the cFT was determined using Vermaulen formula, and the level of IL-10 expression was measured semi-quantitatively by immunofluorescence.

Results: A total of 15 male patients with RHD (mean age 38 years) were involved in the analyses. The age of patients was correlated with cFT (r= -0.6, p= 0.01), but was not correlated significantly with the level of IL-10 (r= 0.27, p= 0.32). Although the mean of cFT level (9.6 ng/dL) was higher than normal reference (>8 ng/dL), there were 8 (53.3%) patients (mean age 47 years) who had a low level of cFT (mean 6.6 ng/dL). Finally, the level of cFT had a moderate inverse correlation with the IL-10 expression level (r = -0.52, p = 0.04).

Conclusion: The level of calculated free testosterone has a moderate inverse correlation with the level of interleukin-10 expression in male patients with RHD. This finding may support the idea that testosterone in male is metabolized in the peripheral tissue, and thus affect the IL-10 expression in patients with RHD.

KEYWORDS : Testosterone, Interleukin-10, Rheumatic Heart Disease

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