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Correlation between Dietary Fat Intake and Physical Activity to Small Dense Low Density Lipoprotein Level in Acute Coronary Syndrome Patients

Author : A. Pudjiastuti, A. A. Asrial, A. Sariningrum, Haryadi, S. N. Sofia
Upload Date : 19-04-2018

Background: High fat dietary intake and sedentary activity were some points of modern lifestyle associated with cardiovascular disease (CVD). High level of total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), high density lipoprotein (HDL), small dense LDL (sdLDL) are marker of atherosclerotic process. Lowering LDL wasn’t absolutely improve the CVD outcome while sdLDL had greater atherogenic potential. sdLDL was better marker to predict CVD. This study want to investigate the correlation of high fat dietary pattern and sedentary activity to sdLDL level and their characteristics in Acute Coronary Syndrome (ACS) patients.

Method: We analyzed 30 patient during May to July 2017 hospitalized with ST elevation Acute Coronary Syndrome (STEACS) and Non-ST Elevation Acute Coronary Syndrome (NSTEACS) in RSUP Dr.Kariadi Semarang. We did nutritional interview using Semiquantitative Food Frequency Questionnaire (SFFQ) to estimate the amount of total fat consumption of the patients. We took daily activity review using Global Physical Activity Questionnaire (GPAQ). We exclude ACS patient who take dyslipidemia medication before and patients with Chronic Kidney and Liver Disease.

Result: There were 18(60%) patients in STEACS group and 12(40%) in NSTEACS group. Both groups were same in age (55.50+11.36 vs 55.25+8.42 years old, p=0.945) and Body Mass Index (BMI) (24.62+2.49 vs 24.70+3.19kg/m2,p=0.472). Patients in STEACS group consumed more fat (61.33+17.29 vs 78.00+29.09 grams, p=0.093). Patients in NSTEACS had more sedentary activity (20% vs 13.7%, p=0.118) than the STEACS group. NSTEACS group had higher TG (144.41+67.77 vs 112.70+46.72mg/dl,p=0.175) and LDL(126.83+34.84 vs 121 + 30.02 mg/dl, p=0.643),lower HDL (33.50+7.81 vs 39.67+18.79 mg/dl,p=0.227). While NSTEACS group had higher TC level (180.33+33.58 vs 177.50+34.69mg/dl,p=0.825). No difference of sdLDL in both groups (26.61+11.34 vs 26.44+10.56, p=0.967). There were significantly positive correlation between total fat intake and sdLDL level in all ACS patients (r=0.439, p=0.015). No correlation was found between physical activity to sdLDL level.

Conclusion: Total fat consumption had significantly positive correlation with sdLDL level in ACS patients. There were no correlation between physical activity level and sdLDL in all ACS patients.

KEYWORDS : Dietary intake, physical activity, smoking, small dense LDL, ACS

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