Advanced

The Association of Blood Glucose Level on Admission and Pre-/Post-procedural TIMI Flow with Mortality in Patients with ST Segment Elevation Myocardial Infarction Undergoing Primary PCI

Author : A. Mahavira, S. Dharma, N. Haryono
Upload Date : 19-04-2018

Background: The association of high blood glucose level and Thrombolysis In Myocardial Infarction (TIMI) flow before/after primary angioplasty with 1-year mortality has not much been explored. Objective:This study sought to determine the association of blood glucose level (BGL) on admission and pre-/post-procedural TIMI flow with 1-year mortality in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI).

Methods: 856 patients with STEMI and treated with primary PCI between January 2014 and July 2016 were retrospectively analyzed. The cut-off used for a high BGL in this study was ≥169 mg/dL. Survival at 1-year was assessed by Kaplan-Meier method.

Results: Patients with BGL ≥169 mg/dL (N=307) had higher proportion of final TIMI flow 0-1 [3.3% vs. 0.5%; adjusted odds ratio (OR)= 5.58, 95% confidence interval (CI) 1.30 to 23.9; p=0.02] and higher 1-year mortality [16.3% vs. 6%; adjusted hazard ratio (HR)= 1.9, 95% CI 1.12 to 3.23, p=0.017] compared with lower BGL patients (N=549). Final TIMI flow 0-1 was an independent predictor of 1-year mortality  (HR= 7.0, 95% CI 3.23 to 15.15; p<0.001). Compared with patients with lower BGL, cumulative survival at 1-year was significantly lower in patients with high BGL (log-rank test, p< 0.001).

Conclusion: Patients with acute STEMI who are presented with high blood glucose level have higher proportion of final TIMI flow 0-1 after primary PCI and are associated with lower survival at 1-year compared with patients with lower BGL. Final TIMI flow 0-1 was found to be an independent predictor of 1-year mortality. Further studies are warranted to evaluate the direct mechanism between high blood glucose and final TIMI flow.

KEYWORDS : STEMI, blood glucose, TIMI flow, 1-year mortality


Save Item
Download
Similar Articles

Predictors of In-Hospital Mortality of ST-Segment Elevation Myocardial Infarction Patients Presenting Beyond First 12 Hours from Symptom Onset: A Two Year Retrospective Analysis National Cardiac Centre Harapan Kita (NCCHK)(W. Firmanda, D. K. Firmansyah, Rizki1, Y. Hendarto, B. Widyantoro, D. Zamroni,I. Firdaus, D. A. Ju)

Effect of Percutaneous Coronary Intervention on Length Of Stay in Late Onset (>12 hours) STEMI Patients with High Degree AV Block.(D. D. A. Sakti, D. Firman, S. Dharma)

Comparison of Cadillac Risk Score and GRACE Risk Score to Predict In-Hospital Major Adverse Cardiac Events in Post Primary Percutaneous Coronary Intervention Patients (A. A. Asrial, A. Pudjiastuti, Haryadi, L. Raharjoyo, N. Virginia, Y. Herry)

The Difference of Admission Blood Glucose and Its Correlation with In-Hospital Cardiovascular Event on Acute Coronary Syndrome Patients at Mohammad Noer Hospital Pamekasan(A. Romdiyana, H.I. Millisani)

Platelet Indices, Infarct Site and In-Hospital Major Adverse Cardiac Events in ST Elevation Myocardial Infarction Patients Undergoing Primary PCI.(A. A. Asrial, A. Pudjiastuti, Haryadi, L Raharjoyo, N. Virginia, Y. Herry)

Correlation between Left Ventricular Ejection Fraction and Zwolle Risk Score in Post Primary Percutaneous Coronary Intervention Patients(A. Pudjiastuti, A. A. Asrial, A. Sariningrum, S. N. Sofia)

Is Admission Hyperglycemia Associated with Reduced Ejection Fraction in ST elevation Myocardial Infarction without Diabetes?(S.P.I Nasruddin , A.A Nursidiq, N. Purwaningtyas. A. Sukmawarti, G. S. Putri)

Comparison of TIMI Flow Between Streptokinase and Alteplase in Patients with ST Elevation Myocardial Infarction After Successful Fibrinolytic at Haji Adam Malik General Hospital Medan(D. Ashrinda, R. Hasan, C. A. Andra, Z. Mukhtar, H. Hasan)

White Blood Cell Count to Mean Platelet Volume Ratio as a Novel Non-Invasive Marker Predicting Short-term Outcomes in Patients with Non-ST Elevation Myocardial Infarction(Y. Saragih, B. Napitupulu, A.N. Nasution, A.H. Raynaldo, H. Hasan)

Resolution of ST-Segment Depression in Reciprocal Leads as a Predictor of Mayor Adverse Cardiac Event for ST-Segment Elevation Myocardial Infarction Treated by Fibrinolytic Therapy(A. S. Adhitya, H. Hasan, A. Sitepu, Z. Mukhtar)

Correlation between Tpeak - Tend Interval and Myocardial Blush Grade Value in Anterior ST-Elevation Myocardial Infarct Patient(R.P. Kaneko, N. Taufiq, E. Maharani.)

Predictors of Hospital Length of Stay Prolongation in Patients with ST-Segment Elevation Myocardial Infarction in Cardiovascular Care Unit Sardjito General Hospital(I.H. Sulistya , H. P. Bagaswoto , N. Taufiq , B. Y. Setianto )

Profile Patient with ST-Elevation Myocardial Infarction Underwent Percutaneous Coronary Intervention at Kariadi Hospital(Y.S. Pratama, S. Sungkar, A. Yudanto, S. Rifqi)

Resolution of ST-Segment, Pain Level, and Arrythmia as A Tool For Assessing The Efficacy of Reperfusion Therapy in STEMI Patient Hospital Kanjuruhan(A. N. Lukito, G. A. Pawintri , A. B. Santoso)

Clinical Profile of patients with Acute Coronary Syndrome in Public Hospital in Bekasi, West Java, Indonesia(B.A.Pratama, J.S. Purnama, K. Priyantoro)

Diagnosing and Treating Left Bundle Branch Block ECG Finding as An Acute Coronary Syndrome Event in Rural Hospital of East Sumba: A Case Report(T.S.R. Sembiring)

Ventricular Tachycardia in Doubt : Usefulness of Brugada and R Wave Peak Time Criteria(Albertus , M. Setiawan )

Raynaud Phenomenon Resistant to the Initial Therapy in Patient with Systemic Lupus Erythematosus(H. Susilo, R.M. Budiarto, H. Anugrawan, R. Amalia)

A 48-years-old Female with Stabbing Chest Pain and Pericardial Effusion: A Case Report(A.K. Ratri*,M.Y. Alsagaff*, T.P. Asmarawati**)

Anterior Extensive ST-Elevation Myocard Infarction With High Thrombus Burden Given Intra-Coronary, Intra-Venous Eptifibatide and Plain Old Balloon Angioplasty : A Case With Satisfying Result(I.N.G.Sudiarta, I.W. Wita)

Coronary Artery Bypass Grafting in ST-Segment Elevation Myocardial Infarction: Option of Reperfusion (Still)(M. Puspitasari, Y.E. Sembiring, M.Y. Alsagaff)

Non-ST Elevation Myocardial Infarction Induced by Sildenafil Consumption in a Patient with No Coronary Artery Disease History: A Case Report(I.M.E.A. Wardhana, P.G. Budiana*)

Recognizing ST-Elevation Myocardial Infarction in Bundle Branch Block(Y.S. Pratama *, R. Puspitoadhi *, P. Ardhianto**, Y. Herry**)

Regional Pericarditis with Reciprocal ECG Changes Mimicking Inferior STEMI(G. M. Rahman, M.Y. Alsagaff)

A Case Report: Transient ST Elevation Myocardial Infarction After Initial Treatment in Emergency Department(R.R. Aryanti, Z. Choa, R.D. Tureno, S. H. Putra)

Copyrights 2018 ASMIHA | Managed by Indonesia Medical Event (IME)