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Differences in Paraoxonase 1 (PON1) and Ox-LDL Serum Level in Coronary Artery Disease and Non Coronary Artery Disease Patients

Author : R. Adriana, Y.H. Oktaviono, D. Soemantri
Upload Date : 19-04-2018

Background: Previous studies shown that oxidative modifications of low-density lipoproteins (Ox-LDL) was playing an important role in the development of atherosclerotic lesions. The LDL oxidation was prevented by high-density lipoprotein (HDL) due to its antioxidant activity, which modulated by an antioxidant enzym paraoxonase-1 (PON1). Thus depleted PON1 serum level increased the risk of coronary artery disease (CAD). This study aimed to investigate  the differences in paraoxonase 1 (PON1) and Ox-LDL serum level  in  coronary artery disease and non coronary artery disease patients

Methods:  This study used a cross sectional approach, which included 22 non-CAD patients with documented normal coronary angiography and 22 CAD patients with documented CAD. Determination of  PON1 and Ox-LDL serum levels was measured by Cusabio-Human OxLDL Elisa-kit and MyBioSource Human Paraoxonase-1 Elisa-kit on Bio rad Microplate Reader 530. 

Results: CAD patients had statistically significant lower PON1 and higher Ox-LDL serum levels compared to non-CAD patients (17.82+15.01vs24.58±14.93, 2.06±.01vs2.05±.01, p<0.05). From the baseline characteristics, by mutivariate regression analysis, fasting glucose had negative effect to PON1 level, while BMI had positive effect with Ox-LDL, which both statistically significant compared with other variables (β -0.319 and β 0.378, p<0.05). From correlation analysis, PON1 has a statistically significant negative association with Ox-LDL in both groups ( r -0.824 dan r -0.681, p<0.05 ).

Conclusion:  Our study conclude that CAD patients have significantly lower PON1 and higher Ox-LDL serum levels compared to non-CAD patients, which strengthens the suggestion that decreased PON1 and increased Ox-LDL serum level could be used as a marker of increased CAD risk. Though PON1 have a statistically significant negative association with Ox-LDL, this finding needs further investigation as various factors such as diet, lifestyle and environmental factors could influence PON1 and Ox-LDL levels.

KEYWORDS : Coronary Artery Disease, Paraoxonase-1, Oxidized LDL


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