Differences in Paraoxonase 1 (PON1) and Ox-LDL Serum Level in Coronary Artery Disease and Non Coronary Artery Disease Patients

Author : R. Adriana, Y.H. Oktaviono, D. Soemantri
Upload Date : 19-04-2018

Background: Previous studies shown that oxidative modifications of low-density lipoproteins (Ox-LDL) was playing an important role in the development of atherosclerotic lesions. The LDL oxidation was prevented by high-density lipoprotein (HDL) due to its antioxidant activity, which modulated by an antioxidant enzym paraoxonase-1 (PON1). Thus depleted PON1 serum level increased the risk of coronary artery disease (CAD). This study aimed to investigate  the differences in paraoxonase 1 (PON1) and Ox-LDL serum level  in  coronary artery disease and non coronary artery disease patients

Methods:  This study used a cross sectional approach, which included 22 non-CAD patients with documented normal coronary angiography and 22 CAD patients with documented CAD. Determination of  PON1 and Ox-LDL serum levels was measured by Cusabio-Human OxLDL Elisa-kit and MyBioSource Human Paraoxonase-1 Elisa-kit on Bio rad Microplate Reader 530. 

Results: CAD patients had statistically significant lower PON1 and higher Ox-LDL serum levels compared to non-CAD patients (17.82+15.01vs24.58±14.93, 2.06±.01vs2.05±.01, p<0.05). From the baseline characteristics, by mutivariate regression analysis, fasting glucose had negative effect to PON1 level, while BMI had positive effect with Ox-LDL, which both statistically significant compared with other variables (β -0.319 and β 0.378, p<0.05). From correlation analysis, PON1 has a statistically significant negative association with Ox-LDL in both groups ( r -0.824 dan r -0.681, p<0.05 ).

Conclusion:  Our study conclude that CAD patients have significantly lower PON1 and higher Ox-LDL serum levels compared to non-CAD patients, which strengthens the suggestion that decreased PON1 and increased Ox-LDL serum level could be used as a marker of increased CAD risk. Though PON1 have a statistically significant negative association with Ox-LDL, this finding needs further investigation as various factors such as diet, lifestyle and environmental factors could influence PON1 and Ox-LDL levels.

KEYWORDS : Coronary Artery Disease, Paraoxonase-1, Oxidized LDL

Save Item
Similar Articles

The Role of New Two Parameters to Improve Diagnostic Accuracy of Treadmill Exercise Test Detect Significant Coronary Artery Disease(M.A. ffendy, G. R. Endamatriza, B. B. Tiksnadi, M. Akbar, A. Purnomowati, T. A. Aprami)

The Relationship Between Fragmented QRS Complex and Coronary Artery Disease in Patient with Total Atrioventricular Nodal Block Requiring Permanent Pacemaker Implantation(M. Rusydi, Y. Yuniadi, S. B. Raharjo, D. Hanafy, D. Yugo)

Distributon of Multiple Vessels Coronary Artery Disease and Risk Factors in Patient with Acute Coronary Syndrome: Study From Sardjito General Hospital Registry(A. Pradhana, H.P. Bagaswoto, N. Taufiq, B.Y. Setianto)

Precordial ST Segment Depression on Admission Electrocardiogram as a Simple Noninvasive Tool for Predicting Coronary Artery Disease Complexity in Patients with Inferior Myocardial Infarction(J. Suganti, A. C. Lubis, A. A. Siregar, A. Sitepu, C. A. Andra, A. N. Nasution, H. Hasan)

The Associtaion between Uric Acid Level with Multivessel Coronary Artery Disease on Patients who Underwent Coronary Angiography in Abdul Wahab Syahranie General Hospital Samarinda(M.D.Pratama, D. Budiono, O.M.S Nasution, D. Herdianto)

Correlation of Lipid Profile with the Severity of Coronary Artery Disease(M.F. Rizky, P.C. Fianirazha, A.H. Rolando, M.W. Hadi, M.N. Afif, S.F. Liliana, S. Imran, U. Ferry )

Association Between Glycated Hemoglobin with Severity of Coronary Artery Disease in Non-Diabetic Patients(I.M Raditya, M. Syafri, M. Yanni)

Age, High Density Lipoprotein Cholesterol and Triglycerides are Correlated with Triple-Vessel Coronary Artery Disease(Y.S. Pratama, U. Bahrudin, S. Sungkar, I. Uddin)

Lipid Profile and It’s Association with Multivessel Coronary Artery Disease on Patients Who Underwent Coronary Angiography in Abdul Wahab Syahranie General Hospital Samarinda(D. Budiono, O.M.S Nasution, M.D.Pratama , D. Herdianto)

Association between Biomarkers and Plaque Vulnerability Detected by Optical Coherence Tomography in Patient with Coronary Artery Disease: a Meta-analysis(U. Bahrudin, R.A. Raharjo, S. Herminingsih, I. Uddin, Hardian, Y. Herry, S. Rifqi)

Copyrights © 2018 ASMIHA | Managed by Indonesia Medical Event (IME)