Circulating Endothelial Microparticles are associated with Major Cardiovascular Events in Patients Thirty Days after Acute Myocardial Infarct

Author : D. S. Mayasari, A. B. Hartopo, H. Mumpuni.
Upload Date : 19-04-2018

Background: Endothelial microparticles (EMPs), which are produced by activated or apoptotic endothelial cells, already known as novel biological markers in endothelial injury that are involved in the pathogenesis of cardiovascular diseases. The aim of this study was to investigate the correlation of EMPs with major cardiovascular events and death after 30 days of acute myocardial infarct.

Methods: Patients with acute myocardial infarct without history of heart failure and previous stent implantation, who were admitted to Sardjito Hospital from January until December 2017 were included in the study. EMPs were taken from the blood samples during 24 hours after admission. Anti-CD31 and anti-CD61 were used for the detection of EMPs by flow cytometry. Follow up was taken at 30 days after the patients had acute myocardial infarct.

Result: Eighty nine patients were enrolled in this study, of which 79 patients completed the study. Major cardiovascular events and death occurred in 20 patients (17%). The level of EMPs in patients with major cardiovascular events were significantly different (271.24±103/µl vs 940.98±233/µl, p=0.04). EMPs level were correlates with major cardiovascular events (p=0.054) in 30 days after acute myocardial infarct.

Conclusion: EMPs level during admission may be useful to identify the major cardiovascular events and death in 30 days after acute myocardial infarction.

KEYWORDS : Endothelial microparticles, major cardiovascular events, acute myocardial infarct

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