Correlation between Dipeptidyl Peptidase-4 Activity and Arterial Stiffness Using Cardio-Ankle Vascular Index in Hypertensive Patients

Author : R. Myrtha, H. Sulastomo, N. Purwaningtyas
Upload Date : 19-04-2018

Background. Cardiovascular disease (CVD) remains the leading cause of death worldwide, despite highly effective preventive treatments. Arterial stiffness is associated with atherosclerotic risk factors and is considered to be a surrogate marker for the development of cardiovascular disease. Subjects with uncontrolled hypertension had a greater prevalence of arterial stiffness (89.9%) than controlled hypertension (59.7%). The risk for CVD events rose from normotension without arterial stiffness to normotension with arterial stiffness and from hypertension without arterial stiffness to hypertension with arterial stiffness. A substantial proportion of treated hypertensives have high arterial stiffness, a finding that may explain some of the notable residual CVD risk associated with even well-controlled hypertension. The aim of this study is to analyze the correlation between plasma DPP-4 activity and arterial stiffness using CAVI in hypertensive subjects

Methods. A cross sectional study was conducted at outpatient clinic, Department of Cardiology and Vascular Medicine, Dr. Moewardi General Hospital, Surakarta, in 44 consecutive hypertensive patients. Plasma DPP-4 activity and CAVI were measured in eligible patients. Clinical, biochemical, dan echocardiographic baseline characteristics were analyzed using independent T-test or chi square. Correlation between plasma DPP-4 activity and CAVI was analyzed using Pearson correlation test. p <0.05 was considered significant.

Results. Plasma DPP-4 activity was increased in hypertensive subjects with high CAVI, but it was not statistically significant. Increased age (r = 0.476; p = 0.001) and decreased creatinine clearance (r = -0.338; p = 0.025) were correlated with CAVI. Sub group analysis in hypertensives treated with ACE inhibitor, plasma DPP-4 activity was strongly correlated with CAVI (r = 0.885; p = 0.008).

Conclusion. Plasma DPP-4 activity was not correlated with arterial stiffness using CAVI in hypertensive patients. In hypertensives treated with ACE inhibitor, plasma DPP-4 activity was strongly correlated with CAVI

KEYWORDS : Dipeptidyl peptidase-4, cardio-ankle vascular index, hypertension.

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